Molecular and Cellular Control of the Nrf1Transcription F...
This study has revealed that Nrf1 is an integral membrane glycoprotein with transmembrane and extramembrane regions, located in both the endoplasmic reticulum (ER) and the nuclear envelope. This CNC/bZIP protein is targeted and anchored in the ER through its N-terminal Homology Box 1 (NHB1) sequence, and in the ER lumen it is glycosylated by amide-linked attachment of glycans to the ...